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Case Reports in Obstetrics and Gynecology
Volume 2012 (2012), Article ID 502919, 3 pages
http://dx.doi.org/10.1155/2012/502919
Case Report

Tetralogy of Fallot Associated with Dysplastic Kidneys, Cloacal Anomalies, and Female Pseudohermaphroditism: A Systemic Anomaly of Septation?

1Servicio de Obstetricia y Ginecología, Hospital de la Plana, Villarreal, Spain
2Servicio de Anatomía Patológica, Hospital de la Plana, Villarreal, Spain

Received 13 March 2012; Accepted 9 May 2012

Academic Editors: S.-Y. Ku and P. McGovern

Copyright © 2012 José Morales-Roselló et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 20-week fetus was diagnosed with tetralogy of Fallot and multicystic kidneys. The postmortem study showed missing müllerian structures with small streak ovaries, external male genitalia, and an abnormal cloacal septation (imperforate anus with a sigmoid colon opening in the bladder). As the observed anomalies were related with septation, a mechanism related with the activation of specific growth factors, we discuss the possibility of a disorder in the function of the bone morphogenetic proteins as a common cause for the widespread anomalies found in this fetus.