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Case Reports in Obstetrics and Gynecology
Volume 2013, Article ID 427141, 5 pages
http://dx.doi.org/10.1155/2013/427141
Case Report

An Unexpected Complete Remission of Advanced Intestinal-Type Vulvar Adenocarcinoma after Neoadjuvant Chemotherapy: A Case Report and a Literature Review

1Department of Gynecology, Obstetrics and Urological Sciences, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy
2Department of Experimental Medicine and Pathology, Sapienza University of Rome, Viale Regina Elena, 324-00161 Rome, Italy

Received 11 August 2013; Accepted 25 September 2013

Academic Editors: M. Hanssens and R. Shaco-Levy

Copyright © 2013 Angela Musella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vulvar cancer represents approximately 3%–5% of all gynecological malignancies. Squamous cell carcinoma is the most frequent histotype, whereas melanomas, adenocarcinomas, basal cell carcinomas, and sarcomas are much less common. Intestinal-type adenocarcinoma is a rare variant of vulvar carcinoma with only few cases found in the literature. The origin of this neoplasia is still much debated, but the most reliable hypothesis is the origin from cloacal remnants that may persist in the adult in different organs. Because of its extremely low incidence, the optimal management of this kind of vulvar cancer is still debated. We report the case of a woman affected by advanced intestinal-type vulvar adenocarcinoma, who achieved a complete clinical and pathological response after neoadjuvant chemotherapeutic treatment with platinum and paclitaxel.