Case Reports in Obstetrics and Gynecology

Case Reports in Obstetrics and Gynecology / 2014 / Article

Case Report | Open Access

Volume 2014 |Article ID 154347 |

Lavinia Domenici, Violante Di Donato, Maria Luisa Gasparri, Francesca Lecce, Jlenia Caccetta, Pierluigi Benedetti Panici, "Laparotomic Myomectomy in the 16th Week of Pregnancy: A Case Report", Case Reports in Obstetrics and Gynecology, vol. 2014, Article ID 154347, 5 pages, 2014.

Laparotomic Myomectomy in the 16th Week of Pregnancy: A Case Report

Academic Editor: P. Schuetze
Received16 Dec 2013
Accepted18 Jan 2014
Published04 Mar 2014


Myomectomy is rarely performed during an ongoing pregnancy because of fear of miscarriage and the risk of an uncontrolled haemorrhage necessitating a hysterectomy. In cases where myomectomy is undertaken, most are performed at the time of cesarean section or with a laparoscopic approach. We report a case of a successful laparotomic myomectomy in the 16th week of pregnancy. A 35-year-old primigravida was admitted to our department with acute abdominal pain and hydronephrosis (serum creatinine 1.6 mg/dL). Imaging revealed a large implant myoma compressing the bladder, ureters, rectus, and gestational chamber and causing hydronephrosis. Laparotomic myomectomy was successfully performed and pregnancy continued uneventfully until the 38th week when a cesarean section was performed. Surgical management of myomas during pregnancy is worth evaluating in well-selected and highly symptomatic cases.

1. Introduction

The estimated prevalence of uterine myomas during pregnancy varies from 0.3 to 15% [1]. Most uterine myomas remain asymptomatic during pregnancy but may result in obstetrical complications in about 10% of cases depending on their size, location, and number [24]. Pain is the main symptom reported in pregnancies with uterine myoma; however, in 2% of patients conservative medical therapy fails. In extreme cases some authors have advocated the interruption of pregnancy to relieve pain [5]. Myomectomy is generally avoided during pregnancy due to the high risk of haemorrhagic or obstetrical complications and no clear unanimous consensus exists, with a surgical approach reserved for cases of intractable abdominal pain and degeneration or rapid growth of myoma [6, 7]. Only a few cases of myomectomy in pregnancy have been reported in the literature [6, 810]. In this paper we report a case of myomectomy of subserous myoma with large base of implant causing hydronephrosis in the 16th week of pregnancy.

2. Case Presentation

In January 2013, a 35-year-old primigravid Caucasian woman (BMI: 22) was referred to our university hospital in the 16th week of gestation for intractable pelvic pain. The medical history was uneventful. The patient reported a sense of pelvic heaviness, changes in urinary habits, lower abdominal discomfort, and unexplained back pain that had worsened over time. She had a normal white blood cell count but an increased value of serum creatinine (1.6 mg/dL). Obstetrical examination showed a large mass at the level of the posterior fornix. Abdominal ultrasound confirmed a viable fetus and a subserous large implant myoma (diameter of 20 cm; Figure 1), a mild bilateral dilatation of the renal pelvis (2 cm on the right-hand side and 3.5 cm on the left), and extrinsic compression of the low ureter with involvement of the initial portion of the ureters.

Magnetic resonance imaging (MRI) confirmed the diagnosis (Figure 2).

Considering the increase in symptoms that were nonresponsive to analgesic therapy, due to organ compression and the level of serum creatinine, after extensive counselling, a myomectomy was planned. Given the volume and the location of the myoma and in order to be able to manage possible complications, laparotomic incision was chosen. After accurate operative field exposure, the huge myoma was removed (Figure 3). Reconstruction of the uterine wall was carried out using a two-layer monofilament absorbable 2.0 suture (Poliglecaprone 25). Other small fibroids were observed but not removed. Estimated blood loss and operation time were 250 cc and 90 minutes, respectively, and no intra- and postoperative complications occurred. An ultrasonographic control of fetal outcome was carried out 7 days after surgery which proved normal. Antibiotics (ampicillin plus sulbactam 3 gr for three times a day) and low molecular heparin were administered for 5 and 10 days, respectively. The patient was dismissed on the 5th postoperative day. Serum creatinine at discharge was 1.1 mg/dL.

Hydroxyprogesterone Caproate (341 mg/2 mL im) was dispensed for 15 days to prevent a possible miscarriage.

The patient was closely followed up with ultrasound and physical examination every four weeks until 24 weeks of gestation, every three weeks from 24 weeks to 34 weeks of gestation, and then every two weeks. Physiological fetal growth and an uneventful antenatal period were reported until 38 weeks of gestation when a cesarean section was performed.

The patient delivered a healthy female baby weighing 3250 gr with Apgar scores of 8 and 9 at one and five minutes, respectively. The maternal haemoglobin level, two days after caesarean section, was 12.2 g/dL. Mother and baby were discharged from the hospital after three days. The 6-week postnatal visit was within the norm.

3. Discussion

Laparotomic myomectomy is generally avoided during an ongoing pregnancy due to higher miscarriage and haemorrhage rates. Most cases are usually performed during a caesarean section at the end of the pregnancy.

In a large study of more than 6300 pregnant women, Coronado et al. reported a 1.9 times greater (95% CI, 1.6 to 2.2) incidence of complications in women with myomas compared with women without myomas [11].

Preterm delivery has been reported in approximately 15–20% of women with myomas, restriction of fetal growth in 10%, and malpresentation in 20% [2].

The increased risk of miscarriage was attributed to the increase in uterine contractions, degeneration, and growth of myoma.

The most common indication for myomectomy during pregnancy is acute severe abdominal pain that does not respond to analgesic therapy due to torsion of the subserous pedunculated myomas or rapid abnormal increase in myoma size, resulting in the compression and displacement of surrounding organs. It has been reported that if symptoms persist after 72 h of pharmacological therapy, surgical intervention must be considered [6, 12, 13].

An analysis of cases reported in the literature suggests that myomectomy during pregnancy can be considered safe. Studies have shown that women who undergo surgical intervention in the second trimester actually have better outcomes than those who opt for conservative management [10, 14] (Table 1).

AuthorPatients numberSymptomsNumber of leiomyomasGestational age at treatment (week)Weight of largest leiomyoma (g)Week and type of deliveryOutcome (birth weight and Apgar score)

Michalas et al., 1995 [17]1Abdominal pain115NA39NA
Danzer et al., 2001 [18]1Abdominal pain and vaginal bleeding112NA37 CSA 3235 g—9/10
B 2810 g—9/10
de Carolis et al., 2001 [12]18Pain, fever, bleeding, 1 threatened miscarriage, 9 asymptomatic1–46–24NA36–41 weeks
14 CS
2 VD
2550–3970 g
Lozza et al., 2011 [15]1Acute urinary retention215 + 5NA35 + 5 CS2280 g—9/9
Joó et al., 2001 [19]1Fetal postural deformity, oligohydramnios125NA40 CS3600 g—good
Celik et al., 2002 [14]5Abdominal pain1–413–22NACS 2800–3600 g—8–10
Hasbargen et al., 2002 [20]1Abdominal pain118157036 CS2495 g—8/8
Umezurike and Feyi-Waboso, 2005 [21]1Abdominal pain130770038 VD3500 g—8/10
Usifo et al., 2007 [22]1Abdominal pain, vomiting, diarrhoea113200038 CS3990 g—good
Suwandinata et al., 2008 [4]1Abdominal pain21564937 Cs2950 g—8/9
Bhatla et al., 2009 [13]1Subacute intestinal obstruction119 + 3390038 VG2740 g—good
Leite et al., 2010 [23]1Abdominal pain117NA39 CS3315 g—9/10
Isabu et al., 2010 [24]1Abdominal pain114NA37 CS2700 g—good
Leach et al., 2011 [5]1Pelvic pain, constipations, urine retention211NA40 + 3 CS4356 g—9/9
Doerga-Bachasing et al., 2012 [9]1Abdominal pain and vomiting110274536 CSNormal—optimal

In Lolis et al.’s study, of 13 patients who underwent myomectomy during pregnancy, only one miscarried, making a success rate of 92% [6].

The majority of interventions described in the literature are performed laparoscopically. Laparoscopy can be considered in selected cases (small, subserous pedunculated myomas). It is a valid option in the surgical management of pregnant women with symptomatic myomas, as it is less invasive and involves minimal postoperative pain and earlier postoperative ambulation [15].

Two cases are reported in the literature with large pedunculated myomas operated by the vaginal route [16].

In our case a laparotomic approach was chosen, because of the size (20 cm), the large base of implant, the location of myoma, and the acute syndrome of the patient.

Although a laparotomic approach for uterine myomas during pregnancy is rarely described, our experience suggests that it can be easily managed laparotomically by an experienced surgeon in selected cases, depending on the size, type, and position of the fibroids.

4. Conclusions

We believe that our experience provides reassurance for pregnant women with uterine myomas: the surgical management of uterine myomas during pregnancy can be successfully performed by expert surgeons on a case-by-case basis. Myomectomy during pregnancy should be performed only if unavoidable. In selected patients it could prevent miscarriage or an unacceptable obstetrical outcome. The surgical approach should be tailored to the patient and to the characteristics of the myoma. Clearly, an expert surgical and anesthesiological team is essential in order to reduce risk of complications.

Further investigation is needed to improve and better define the safety and feasibility of laparotomic myomectomy during pregnancy.

Conflict of Interests

All authors declare no conflict of interests.


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Copyright © 2014 Lavinia Domenici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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