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Case Reports in Obstetrics and Gynecology
Volume 2014 (2014), Article ID 314587, 3 pages
Case Report

Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids

1Department of Obstetrics and Gynecology, La Fe University Hospital, Bulevar Sur s/n, 46026 Valencia, Spain
2Instituto Valenciano de Infertilidad (IVI), 08017 Barcelona, Spain

Received 7 April 2014; Revised 9 July 2014; Accepted 10 July 2014; Published 21 July 2014

Academic Editor: Yoshio Yoshida

Copyright © 2014 Javier Monleón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial cavity were noted by transvaginal ultrasound after treatment. An endometrial biopsy excluded histologic endometrial changes. Three months after the end of UA the patient reported amenorrhea for 5 weeks and a clinical pregnancy was confirmed with transvaginal ultrasound. She underwent a subsequent uneventful pregnancy. Thus, the spontaneous pregnancy after UA to reduce fibroid size may support the potential clinical utility of this selective progesterone receptor modulator in the management of women with pregnancy desire and uterine fibroids after a prior myomectomy. Patients who refuse a new surgical procedure and/or those who are going to undergo assisted reproductive techniques would benefit from UA. It effectively shrinks fibroids, avoids risks of a new surgical procedure, and allows an immediate attempt at conception after the end of treatment.