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Case Reports in Obstetrics and Gynecology
Volume 2014, Article ID 714271, 5 pages
Case Report

Short and Long Term Outcomes Associated with Fetal Cholelithiasis: A Report of Two Cases with Antenatal Diagnosis and Postnatal Follow-Up

1Department of Obstetrics and Gynecology, Ultrasound and Fetal Medicine Unit, University Hospital of Canary Islands, Ctra. Ofra, s/n, Santa Cruz de Tenerife, 38320 San Cristóbal de La Laguna, Spain
2Department of Obstetrics and Gynecology, School of Medicine, University Hospital Policlinico of Bari and University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy
3Department of Obstetrics and Gynecology, University Hospital Puerta de Hierro, Calle Manuel de Falla, 1 Majadahonda, 28222 Madrid, Spain

Received 11 August 2014; Accepted 19 September 2014; Published 30 September 2014

Academic Editor: Giovanni Monni

Copyright © 2014 Juan Troyano-Luque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aims of this study were to present and discuss ultrasound findings of prenatal fetal cholelithiasis in two cases with different etiology and evolution. Case 1: a pregnant woman from sub-Saharan Africa, suffering from Lyme disease, was treated with ceftriaxone sodium. Six weeks later, biliary sludge associated with polyhydramnios was detected in the fetus and the fetal growth percentile was 14. Emergency caesarean was performed at 36 weeks of gestation due to fetal distress. Biliary sludge persists in the two-and-a-half-year-old child. Case 2: the fetus of a Caucasian woman with normal pregnancy showed multiple cholelithiasis associated with polyhydramnios at 31 weeks of gestation. At 39 weeks and 4 days, cesarean section was performed due to lack of dilation. The biliary disease resolved spontaneously at seven months of age, with no associated abnormalities. In conclusion, prenatal diagnosis of cholelithiasis is straightforward, but prognosis cannot be defined yet. Serious complications do not arise in 70% of cases, but severe diseases may ensue in 20%. Persistence of cholelithiasis after one year of age results in cholelithiasis in childhood and beyond. Biliary sludge is associated with worse prognosis than cholelithiasis when it appears before 28 weeks of gestation.