Gynecologic Malignancies Post-LeFort Colpocleisis

Table 1

Gynecologic malignancies post-LeFort colpocleisis.

Author [reference]	Year	Diagnosed malignancy	Cases within a LFC series or reported individually	Age at diagnosis (years)	Presentation	Approximate interval between LFC and malignancy diagnosis	Diagnostic modality	Treatment
Mazer and Israel [4]	1948	Endometrial adenocarcinoma	1 in 43	62	Vaginal bleeding	9 years	TAH BSO	Unspecified radiation therapy
Falk and Kaufman [5]	1955	Endometrial adenocarcinoma	1 in 100	Unspecified	Vaginal bleeding	Unspecified	TAH	None
Hanson and Keettel [6]	1969	Endometrial adenocarcinoma	1 in 288	Unspecified	Vaginal bleeding	3 years	Colpocleisis take down, D & C	ICR, TAH BSO
		Endometrial adenocarcinoma	1	91	Vaginal bleeding	16 years	D & C	ICR
		Unspecified^*	1	Unspecified	Unspecified	Unspecified	Unspecified	Unspecified
Sudo et al.,; [7]	1976	Ovarian: papillary adenocarcinoma	1	56	Vaginal bleeding	3 years	Dilation of lateral channel, D & C	TAH BSO, external pelvic radiotherapy
Yamakawa et al., [2]	1998	Cervical: squamous cell carcinoma	1	89	Purulent vaginal discharge and bleeding	7 years	Papanicolaou test, abdominal/pelvic CT	None (patient deceased prior to treatment)
Cho et al., [8]	2011	Vaginal: squamous cell carcinoma	1	75	Recurrent purulent vaginal discharge and perianal pain	1 year, 4 months	Pelvic CT, Biopsy	External pelvic radiotherapy
Harmanli et al., [3]	2013	Endometrial: clear cell carcinoma	1	74	Vaginal bleeding	1 year, 2 months	Transvaginal-channel hysteroscopy, D & C	Robotic TLH BSO, lymphadenectomy
Total = 9

Per Hanson and Keettel [6] prior to 1936, only 1 case report of malignancy developing after a LeFort operation had appeared in the literature. The type of cancer was not specified, however.
Legend: TAH: total abdominal hysterectomy; TLH: total laparoscopic hysterectomy; BSO: bilateral salpingooophorectomy; D & C: dilation and curettage; ICR: intracavitary radium; CT: computed tomography.