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Case Reports in Obstetrics and Gynecology
Volume 2015 (2015), Article ID 324173, 3 pages
http://dx.doi.org/10.1155/2015/324173
Case Report

Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum

1Department of Obstetrics and Gynecology, University of South Carolina School of Medicine Greenville, Greenville Health System, 890 W. Faris Road, Suite 470, Greenville, SC 29605, USA
2Greenwood Genetic Center, 14 Edgewood Drive, Greenville, SC 29605, USA
3Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Carolina School of Medicine Greenville, Greenville Health System, 890 W. Faris Road, Suite 470, Greenville, SC 29605, USA

Received 14 May 2015; Accepted 30 July 2015

Academic Editor: Line Bjørge

Copyright © 2015 Andrew S. Lane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 21-year-old primigravida had a pregnancy complicated by hyperemesis gravidarum (HG) beginning at 7-week gestation. Despite medical therapy, she lost 18% of her prepregnancy weight. Early ultrasound at 14 weeks demonstrated a flattened facial profile with nasal hypoplasia (Binder phenotype) consistent with vitamin K deficiency from HG. She had a percutaneous endoscopic gastrojejunostomy tube placed for enteral feeding at 15-week gestation. At repeated anatomy ultrasound at 21-week gestation, delivery, and postnatal pediatric genetics exam, nasal hypoplasia was consistent with vitamin K deficiency embryopathy from HG. Nausea and vomiting of pregnancy is a common condition. HG, the most severe form, has many maternal and fetal effects. Evaluation of vitamin K status could potentially prevent this rare and disfiguring embryopathy.