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Case Reports in Obstetrics and Gynecology
Volume 2015, Article ID 690891, 5 pages
http://dx.doi.org/10.1155/2015/690891
Case Report

Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination

1Department of Pathology, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
2Department of Diagnostic Pathology, Miyazaki University Hospital, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
3Department of Gynecology and Obstetrics, Koga Hospital, 1749-1 Sudaki, Ikeuchi, Miyazaki 880-0041, Japan

Received 27 February 2015; Revised 27 April 2015; Accepted 27 April 2015

Academic Editor: Anna Fagotti

Copyright © 2015 Eriko Nakamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature.