A Case of New-Onset Dermatomyositis in the Second Trimester of Pregnancy: A Case Report and Review of the Literature

Table 1

Dermatomyositis complicating pregnancy. Review of the cases.

Author [ref.]	Patient	Age at diagnosis (years)	DM onset	Disease activity (during pregnancy)	Treatment	Fetal outcome
Glickman [7]	1	27	BP	Improved	Prednisone	Healthy
Masse [8]	1	26	BP	Improved	ACTH	Healthy
				Inactive	ACTH	Abortion
Tsai et al. [9]	1	33	DP	Active	No treatment	Neonatal death
Gutierrez et al. [6]	1	NI	DP	Active	Prednisone	Abortion
	2	NI	DP	Active	Prednisone	Stillbirth
	3	JDM	BP	Inactive	No treatment	Abortion
				Exacerbation	Prednisone	Premature
	4	NI	PP	Inactive	No treatment	Abortion
				Inactive	No treatment	Caesarean at term
	5	NI	BP	Inactive	No treatment	Healthy
	6	NI	BP	Exacerbation	Prednisone	Premature
				Inactive	No treatment	Twins Premature/neonatal death
King and Chow [10]	1	12	BP	Inactive	No treatment	IUGR
				Inactive	No treatment	Healthy
	2	20	BP	Inactive	No treatment	Healthy
				Inactive	No treatment	Healthy
	3	25	BP	Exacerbation	Prednisone	Healthy
England et al. [11]	1	35	DP	Active	Steroid	IUGR
Ishii et al. [12]	1	31	DP	Active	Steroid	Healthy
				Inactive	Steroid	Healthy
Pinheiro Gda et al. [2]	1	14	DP	Active	Steroid	Healthy
Suwa et al. [13]	1	29	PP	—	Spontaneous remission	—
Harris et al. [14]	1	29	DP	Active	Induced labor, pulse steroid PP	Healthy
Solomon and D’Alton [15]	1	28	DP	Active	Steroid	Healthy
Kofteridis et al. [16]	1	25	DP	Active	Pulse steroid	Abortion
Kanoh et al. [17]	1	33	PP	—	Prednisolone PP	—
Lee and Yoo [18]	1	33	PP	—	Methylprednisolone PP	—
Silva et al. [4]	1	22	BP	Active, no change	Steroid, MTX	Abortion
	2	28	BP	Inactive	Prednisolone	Healthy
Park et al. [19]	1	22	DP	Active	Therapeutic abortion, IVIG PP	Abortion
Mosca et al. [20]	1	32	DP	Active	Methylprednisolone, IVIG	Healthy
Pasrija et al. [21]	1	27	DP	Active	Dexamethasone, HCQ	Healthy
Váncsa et al. [22]	1	22	BP	Inactive	Methylprednisolone	Healthy
				Inactive	Methylprednisolone	Abortion
	2	28	BP	Inactive	Methylprednisolone	Healthy
	3	33	BP	Inactive	No treatment	Healthy
	4	37	DP	Active	Methylprednisolone	Premature
	5	30	BP	Inactive	No treatment	Healthy
Chopra et al. [23]	1	28	BP	Inactive	No treatment	Healthy
				Inactive	No treatment	IUGR
Nozaki et al. [24]	1	31	DP	Active	Prednisolone, IVIG PP	Premature
Linardaki et al. [25]	1	42	DP	Active	Methylprednisolone, IVIG	Healthy
Madu et al. [26]	1	JDM	BP	Exacerbation	Prednisolone	Healthy
Pinal-Fernandez et al. [3]	1	35	BP	Improvement	Prednisone, MTX	Induced abortion
				Improvement	Prednisone	Healthy
				Improvement	Prednisone	Healthy
	2	35	BP	Improvement	Prednisone	Healthy
				Improvement	Prednisone	Healthy
	3	38	BP	Improvement	Prednisone	Induced abortion (anencephaly)
				Improvement	Prednisone	Healthy
				Improvement	Prednisone	Healthy
	4	32	PP	—	Prednisone PP	—
	5	31	BP	Asymptomatic	No treatment	Healthy
				Asymptomatic	No treatment	Abortion
	6	36	BP	No change	Prednisone	Healthy
Present case	1	40	DP	Active	Methylprednisolone	Premature

BP, before pregnancy; DP, during pregnancy; PP, puerperal period; NI, not indicated; JDM, juvenile dermatomyositis; ACTH, adrenocorticotrophic hormone; IVIG, intravenous immunoglobulin; MTX, methotrexate; HCQ, hydroxychloroquine; IUGR, intrauterine growth restriction.