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Case Reports in Obstetrics and Gynecology
Volume 2016, Article ID 6841989, 4 pages
Case Report

Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge

1Department of Pathology, University of California San Diego, 200 W. Arbor Drive MC 8320, San Diego, CA 92103, USA
2Department of Surgery, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093, USA
3Kaiser Permanente, 10800 Magnolia Ave., Riverside, CA 92505, USA
4Department of Reproductive Medicine, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093, USA

Received 15 July 2016; Accepted 5 October 2016

Academic Editor: Kyousuke Takeuchi

Copyright © 2016 Vera Vavinskaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can be classified according to whether or not they are confined to the appendix. Although LAMNs are frequently confined to the appendix, they can also spread to the peritoneum and clinically progress as pseudomyxoma peritonei (i.e., mucinous ascites). Thus, the appropriate classification of appendiceal primary neoplasia is essential for prognosis and influences clinical management. In addition, the precise classification, management, and clinical outcome of patients with disseminated peritoneal disease remain controversial. Here, we report an unusual case of LAMN with pseudomyxoma peritonei that initially presented with mucinous and bloody vaginal discharge. Pathological evaluation revealed low-grade appendiceal mucinous neoplasm with secondary involvement of the peritoneum, ovaries, and endometrial surface. Therefore, LAMN should be considered in the differential diagnosis of mucinous vaginal discharge.