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Case Reports in Obstetrics and Gynecology
Volume 2016, Article ID 9737014, 3 pages
Case Report

Two Cases of Endometrial Cancer in Twin Sisters with Myotonic Dystrophy

Department of Obstetrics & Gynecology, Onze Lieve Vrouwe Gasthuis, 1091 AC Amsterdam, Netherlands

Received 5 May 2016; Accepted 19 July 2016

Academic Editor: Anna Fagotti

Copyright © 2016 Ezra Y. Koh and Paul J. M. van Kesteren. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We describe two cases of endometrial cancer (EC) occurring in nulligravid twin sisters with myotonic dystrophy. Both tested negative for Lynch syndrome and both were treated with laparoscopic hysterectomy with bilateral salpingooophorectomy and adjuvant radiotherapy. Although EC tends to run in families, the diagnosis in itself is not considered sufficient cause for screening or prophylactic measures in close relatives. However, the presence of additional risk factors, such as nulligravidity and myotonic dystrophy in the underlying cases, may call for extra vigilance in first-degree family members.