Should Prophylactic Anticoagulation Be Considered with Large Uterine Leiomyoma? A Case Series and Literature Review

Table 1

All case reports of thromboembolic disease and uterine leiomyoma according to our literature review.

Reference	Year	Number of cases	Age	Diagnosis	Etiology	Treatment	Outcome
Ogawa et al.	1992	1	49 y.o	Lower extremity DVT + PE	Compression of the left external iliac vein	Pulmonary embolectomy + hysterectomy	Survived
Dekel et al.	1998	1	45 y.o	Lower extremity DVT	Compression of pelvic veins	Anticoagulation + IVC filter + hysterectomy	Survived
Chong et al.	1998	2	43 y.o	Lower extremity DVT	Compression of the IVC	IVC filter + hysterectomy	Survived
			49 y.o	Bilateral lower extremity DVT	No compression seen in images	Anticoagulation + hysterectomy	Survived
Nishikawa and Ideishi	2000	1	51 y.o	Lower extremity DVT + PE	Compression of pelvic vein	Anticoagulation + IVC filter + hysterectomy	Survived
Stanko et al.	2001	1	49 y.o	Lower extremity DVT	Compression of the left iliofemoral vein	Anticoagulation + IVC filter + hysterectomy	Survived
Phupong et al.	2001	1	42 y.o	Lower extremity DVT	Compression of the pelvic veins	Anticoagulation + hysterectomy	Survived
Tanaka et al.	2002	2	46 y.o	Lower extremity DVT + PE	Compression of pelvic veins	Anticoagulation + IVC filter + hysterectomy	Survived
			45 y.o	Lower extremity DVT	Compression of pelvic veins	Thrombolysis + anticoagulation + IVC filter + hysterectomy	Survived
Srivatsa et al.	2005	1	35 y.o	Bilateral internal iliac thrombi	Compression of the common iliac and inferior vena cava	Anticoagulants	Survived
Falcone and Serra	2005	1	39 y.o	Massive PE	Pelvic vein compression	Thrombolysis + anticoagulation + hysterectomy	Survived
Hawes et al.	2006	1	35 y.o	Lower extremity DVT	Compression of the distal inferior vena cava	Anticoagulants + hysterectomy	Survived
Bonito and Gulemi	2007	1	49 y.o	Lower extremity DVT + PE	Compression of pelvic veins	IVC filter + hysterectomy	Survived
Bekhit et al.	2007	1	55 y.o	Bilateral lower extremity DVT	Compression of pelvic veins + Tamoxifen use	IVC filter + hysterectomy	Survived
Khilanani and Dandolu	2007	1	44 y.o	Lower extremity DVT	Compression of inferior vena cava	IVC filter + hysterectomy	Survived
Asciutto and Mumme	2008	1	42 y.o	Lower extremity DVT	Compression of left iliac vein	Thrombectomy + hysterectomy	Survived
Kutsukata et al.	2009	1	42 y.o	Lower extremity DVT	Compression of inferior vena cava	Anticoagulation + thrombectomy + IVC filter + hysterectomy	Survived
Chandra et al.	2010	1	47 y.o	Lower extremity DVT	Compression of pelvic veins	Anticoagulation + hysterectomy	Survived
Huffman-Dracht and Coates	2010	1	37 y.o	Lower extremity DVT + PE	Compression of pelvic veins	IVC filter + anticoagulation	Loss to follow-up
Rosenfeld and Byard	2012	1	44 y.o	Lower extremity DVT + PE	Compression of pelvic veins	N/A	Died
Kurakazu et al.	2012	1	40 y.o	PE	Compression of iliac veins	Thrombolysis + hysterectomy	Survived
Srettabunjong	2013	1	46 y.o	Bilateral lower extremity DVT + massive PE	Compression of pelvic veins	N/A	Died
Toru et al.	2013	1	42 y.o	Lower extremity DVT	Compression at the bifurcation of the inferior cava	Anticoagulation	Loss to follow-up
Khademvatani et al.	2014	1	42 y.o	Lower extremity DVT + PE	Compression of common iliac veins	Thrombolysis + myomectomy	Survived
Fernandes et al.	2014	1	29 y.o	Lower extremity DVT + PE	Compression of iliac veins	Anticoagulation + hysterectomy	Survived