Vaginal Angiomyofibroblastoma: A Case Report and Review of Diagnostic Imaging

Table 1

Clinical and pathologic features of AMFB and AA.

	AMFB	AA
Clinical features
Age (years)	16 – 86 (Median 45)	16 – 70 (Median 37)
Size (cm)	< 5 (0.5 – 23)	>5 (1-60)
Location	Female pelvis and perineum: predominantly vulvar/vaginal	Female pelvis and perineum
Onset	1 month to 8 years	1 month – 5 years
	Predominantly 1-2 years	Predominantly < 1 year
Recurrence	None reported	33-72%
Pathology
Low-power features	Well-defined	Infiltrative
	No entrapment of mucosal glands or nerve bundles	Entrapped mucosal glands and nerve bundles
	Alternating hypocellular and hypercellular areas	Stromal cells distributed throughout
Vasculature	Abundant thin-walled vessels, mostly capillary-like	Small to medium-sized vessels, mostly thick-walled or hyalinized
Stromal cells	Abundant	Low cellularity
	Spindle, plump spindle, or oval	Thin delicate spindle or stellate
	Perivascular aggregation	Mitotic figures typically absent
	Mitotic figures typically absent
Stroma	Mucin-poor, containing delicate, wavy collagen fiber	Myxoid, hyaluronic-acid rich
Immunostaining
Desmin	Positive (50-60%)	Positive (Up to 73%)
–SMA	Negative (positive in up to 15%)	Positive
S-100	Negative	Negative
Vimentin	Positive	Positive
Estrogen receptor	Positive	Positive
Progesterone receptor	Positive	Positive