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Case Reports in Obstetrics and Gynecology
Volume 2018, Article ID 8706738, 3 pages
Case Report

Latent Syphilis Infection in Pregnancy: An Ultrasound Diagnosed Case of Penicillin Treatment Failure

1Maternal and Child Department, Careggi University Hospital Florence, Florence, Italy
2Infectious Disease Unit, Careggi University Hospital Florence, Florence, Italy

Correspondence should be addressed to Lucia Pasquini; ti.nit@iniuqsapaicul

Received 5 April 2018; Accepted 15 July 2018; Published 26 July 2018

Academic Editor: A. O. Awonuga

Copyright © 2018 Lucia Pasquini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a case of early latent syphilis (reactive serologic tests without clinical evidence of disease within 24 months from the onset of the infection) in pregnancy. Despite an appropriate maternal treatment with benzathine penicillin G, sonographic signs of fetal syphilis were detected. Follow-up scans, in addiction to serial serological tests, have allowed the identification of fetal infection and therefore the failure of antibiotic therapy. We highlight the importance of ultrasound in suspecting fetal infection and in evaluation of the fetal response after penicillin treatment.