Ritodrine-Induced Agranulocytosis: A Case Report and Literature Review

Table 2

The 47 cases found in our literature review of ritodrine hydrochloride-induced agranulocytosis in pregnancy.

Mean maternal age (range) (years)	29.6 (21-40)
Multiparous (%)	15 (31.9)
Multiple pregnancy (%)	14 (29.8)
Ritodrine therapy
Mean duration (range) (days)	30.3 (21-69)
Mean cumulative dose (range) (mg)	6,642 (2,000-17,700)
Labor date at onset of agranulocytosis
WBC (range) (/μl)	1,864 (790-3,500)
Granulocyte (range) (/μl)	216 (0-1,925)
Concomitant drug
Magnesium sulfate (%)	17 (36.2)
Indomethacin (%)	5 (10.6)
Infection signs (%)	21 (44.7)
Antibacterial (%)	31 (66.0)
G-CSF (%)	35 (74.5)
Preterm birth (%)	25 (53.2)