Authors/year of publication Gestational age (weeks)/remarks Description of leiomyoma/size of uterus Description of intervention Induction to abortion time Saad-Naguib et al. [7 ] 9 1 mEq/mL of fetal intracardiac potassium chloride injection followed by 2 doses of 20 mg/m2 methotrexate 2 weeks Mark et al. [8 ] 10-20 Uterine sizes range from 16- to 32-week pregnancy For patients up to 14-week pregnancy, 200 mg of oral mifepristone followed by 2 doses of 800 μ g misoprostol vaginally 24 and 48 hμ g of misoprostol vaginally every 4–6 h until delivery 6-17 h Seto et al. [9 ] 14 Dilapan®-S1 intracervically 12 h before 3 doses of misoprostol vaginally every 4 h (50, 100, and 150 μ g, respectively) 9.5 h after first dose of misoprostol Li et al. [10 ] 6 Nine measurable leiomyomata, the largest of which measured 3 tablets of 200 mg mifepristone and 3 tablets of 200 μ g misoprostol 48 h later and then 5 tablets of 200 μ g misoprostol vaginally NA2 Dalton and Lebovic [11 ] 11 Multiglobular, heterogenous masses with the largest’s diameter measuring 8 cm in the posterior corpus, extending cephalad, and caudad2 Surgical abortion using a flexible cannula NA2 Fenwick and Divers [12 ] 6 600 mg mifepristone orally, followed by 1 mg gemeprost vaginally after 36 h NA2 Creinin [13 ] 6-7 Multiple leiomyomata 104 mg of methotrexate intramuscularly, followed by four tablets of 200 μ g misoprostol vaginally 6 days later 3 h after first dose of misoprostol Buckshee and Dhond [14 ] 10 Large multiple leiomyomata Intra-amniotic and intraplacental instillation of methotrexate, 25 mg at each site 8 days
