Case Report
Pheochromocytoma/Paraganglioma (PPGL): A Misdiagnosed Cause of Hypertension during Pregnancy
Table 1
Clinical data from the two patients diagnosed with PPGL during pregnancy.
| | Case 1 | Case 2 |
| Age at diagnosis | 25 years | 22 years | Gestational age | 31 weeks | 18 weeks | Clinical history and symptoms | Hypertension, hyperglycemia, sweating, palpitations since before pregnancy | Hypertension during paroxysms | Plasma NMN/MN | 10x ULN/normal | — | Urinary NMN/MN | — | 10x ULN/normal | Molecular study | None GPV detected | MAX deletion exon 1-3 | Surgical management | C-section at 32nd week, no previous adrenergic blockade; laparoscopic excision 4 mo later | Laparoscopic tumor excision at 23 wks, 15 days after alpha-adrenergic blockade | Maternal and fetal complications | Hypertensive crisis during C-section; no further clinical repercussions | None |
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NMN = normetanephrine; MN = metanephrine; ULN = upper limit of normal.
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