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Case Reports in Oncological Medicine
Volume 2012, Article ID 257814, 3 pages
Case Report

Laryngeal Involvement of Multiple Myeloma

1Department of Otolaryngology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 572, Miami, FL 33136, USA
2Department of Pathology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, 14th Floor, Miami, FL 33136, USA

Received 21 September 2012; Accepted 27 October 2012

Academic Editors: J. M. Buchanich, J. I. Mayordomo, B. I. Razzouk, and G. P. Vandoros

Copyright © 2012 Ariel B. Grobman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.