Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2012, Article ID 313057, 11 pages
http://dx.doi.org/10.1155/2012/313057
Case Report

All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia: A Case Report and Literature Review

1Floyd & Delores Jones Cancer Institute, Virginia Mason Medical Center, Seattle, WA 98101, USA
2Department of Pathology, Virginia Mason Medical Center, 1100 Seattle, WA 98101, USA
3Division of Hematology, University of Washington, Seattle, WA 98195, USA

Received 5 February 2012; Accepted 1 April 2012

Academic Editors: S. Aksoy, M. W. Bekkenk, A. Goodman, and O. Ozyilkan

Copyright © 2012 Dylan Holmes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Stone and R. J. Mayer, “The unique aspects of acute promyelocytic leukemia,” Journal of Clinical Oncology, vol. 8, no. 11, pp. 1913–1921, 1990. View at Google Scholar · View at Scopus
  2. R. P. Warrell Jr., H. De The, Z. Y. Wang, and L. Degos, “Acute promyelocytic leukemia,” New England Journal of Medicine, vol. 329, no. 3, pp. 177–189, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. F. R. Davey, R. B. Davis, J. M. MacCallum et al., “Morphologic and cytochemical characteristics of acute promyelocytic leukemia,” American Journal of Hematology, vol. 30, no. 4, pp. 221–227, 1989. View at Google Scholar · View at Scopus
  4. R. A. Larson, K. Kondo, and J. W. Vardiman, “Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia,” American Journal of Medicine, vol. 76, no. 5, pp. 827–841, 1984. View at Google Scholar · View at Scopus
  5. R. Mertelsmann, H. T. Thaler, and L. To, “Morphological classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia,” Blood, vol. 56, no. 5, pp. 773–781, 1980. View at Google Scholar · View at Scopus
  6. G. J. Ventura, J. P. Hester, D. O. Dixon, S. Khorana, and M. J. Keating, “Analysis of risk factors for fatal hemorrhage during induction therapy of patients with acute promyelocytic leukemia,” Hematologic Pathology, vol. 3, no. 1, pp. 23–28, 1989. View at Google Scholar · View at Scopus
  7. M. S. Tallman, J. W. Andersen, C. A. Schiffer et al., “All-trans-retinoic acid in acute promyelocytic leukemia,” New England Journal of Medicine, vol. 337, no. 15, pp. 1021–1028, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Tallman, D. Douer, S. Gore et al., “Treatment of patients with acute promyelocytic leukemia: a consensus statement on risk-adapted approaches to therapy,” Clinical Lymphoma, Myeloma and Leukemia, vol. 10, supplement 3, pp. S122–S126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Lo-Coco, G. Avvisati, M. Vignetti et al., “Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group,” Blood, vol. 116, no. 17, pp. 3171–3179, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Fenaux, C. Chastang, S. Chevret et al., “A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia,” Blood, vol. 94, no. 4, pp. 1192–1200, 1999. View at Google Scholar · View at Scopus
  11. M. A. Sanz, D. Grimwade, M. S. Tallman et al., “Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet,” Blood, vol. 113, no. 9, pp. 1875–1891, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Simzar, A. M. Rotunda, and N. Craft, “Scrotal ulceration as a consequence of all-trans-retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia,” Journal of Drugs in Dermatology, vol. 4, no. 2, pp. 231–232, 2005. View at Google Scholar · View at Scopus
  13. R. Jeddi, K. Kacem, H. B. Neji et al., “Predictive factors of all-trans-retinoic acid related complications during induction therapy for acute promyelocytic leukemia,” Hematology, vol. 13, no. 3, pp. 142–146, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. K. L. Vanier, A. J. Mattiussi, and D. L. Johnston, “Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia,” Journal of Pediatric Hematology/Oncology, vol. 25, no. 5, pp. 403–404, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. E. R. G. Ang, J. C. C. Zimmerman, and E. Malkin, “Pseudotumor cerebri secondary to minocycline intake,” Journal of the American Board of Family Practice, vol. 15, no. 3, pp. 229–233, 2002. View at Google Scholar · View at Scopus
  16. D. I. Friedman and D. M. Jacobson, “Diagnostic criteria for idiopathic intracranial hypertension,” Neurology, vol. 59, no. 10, pp. 1492–1495, 2002. View at Google Scholar · View at Scopus
  17. A. G. Lee and M. Wall, Idiopathic Intracranial Hypertension (Pseudotumor Cerebri): Clinical Features and Diagnosis, UpToDate, Waltham, Mass, USA, 2010.
  18. S. J. Wang, S. D. Silberstein, S. Patterson, and W. B. Young, “Idiopathic intracranial hypertension without papilledema: a case- control study in a headache center,” Neurology, vol. 51, no. 1, pp. 245–249, 1998. View at Google Scholar · View at Scopus
  19. G. Visani, G. Bontempo, S. Manfroi, A. Pazzaglia, R. D'Alessandro, and S. Tura, “All-trans-retinoic acid and pseudotumor cerebri in a young adult with acute promyelocytic leukemia: a possible disease association,” Haematologica, vol. 81, no. 2, pp. 152–154, 1996. View at Google Scholar · View at Scopus
  20. Y. C. Yeh, H. F. Tang, and I. M. Fang, “Pseudotumor cerebri caused by all-trans-retinoic acid treatment for acute promyelocytic leukemia,” Japanese Journal of Ophthalmology, vol. 50, no. 3, pp. 295–296, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. B. L. Powell, B. Moser, W. Stock et al., “Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710,” Blood, vol. 116, no. 19, pp. 3751–3757, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. S. Tallman, J. W. Andersen, C. A. Schiffer et al., “All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol,” Blood, vol. 100, no. 13, pp. 4298–4302, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Jindal, L. Hiam, A. Raman, and D. Rejali, “Idiopathic intracranial hypertension in otolaryngology,” European Archives of Oto-Rhino-Laryngology, vol. 266, no. 6, pp. 803–806, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. D. K. Binder, J. C. Horton, M. T. Lawton et al., “Ideopathic intracranial hypertension,” Neurosurgery, vol. 54, no. 3, pp. 538–552, 2004. View at Google Scholar · View at Scopus
  25. G. A. Bateman, S. A. Stevens, and J. Stimpson, “A mathematical model of idiopathic intracranial hypertension incorporating increased arterial inflow and variable venous outflow collapsibility: clinical article,” Journal of Neurosurgery, vol. 110, no. 3, pp. 446–456, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Ireland, J. J. Corbett, and R. B. Wallace, “The search for causes of idiopathic intracranial hypertension. A preliminary case-control study,” Archives of Neurology, vol. 47, no. 3, pp. 315–320, 1990. View at Google Scholar · View at Scopus
  27. V. Giuseffi, M. Wall, P. Z. Siegel, and P. B. Rojas, “Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study,” Neurology, vol. 41, no. 2, pp. 239–244, 1991. View at Google Scholar · View at Scopus
  28. I. U. Scott, R. M. Siatkowski, M. Eneyni, M. C. Brodsky, and B. L. Lam, “Idiopathic intracranial hypertension in children and adolescents,” American Journal of Ophthalmology, vol. 124, no. 2, pp. 253–255, 1997. View at Google Scholar · View at Scopus
  29. P. J. Francis, S. Haywood, S. Rigden, D. M. Calver, and G. Clark, “Benign intracranial hypertension in children following renal transplantation,” Pediatric Nephrology, vol. 18, no. 12, pp. 1265–1269, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Serratrice, B. Granel, J. Conrath et al., “Benign intracranial hypertension and thyreostimulin suppression hormonotherapy,” American Journal of Ophthalmology, vol. 134, no. 6, pp. 910–911, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. M. R. Rickels and C. W. Nichols, “Pseudotumor cerebri in patients with cushing's disease,” Endocrine Practice, vol. 10, no. 6, pp. 492–496, 2004. View at Google Scholar · View at Scopus
  32. S. H. Levine and C. Puchalski, “Pseudotumor cerebri associated with lithium therapy in two patients,” Journal of Clinical Psychiatry, vol. 51, no. 6, pp. 251–253, 1990. View at Google Scholar · View at Scopus
  33. S. L. Blethen, “Complications of growth hormone therapy in children,” Current Opinion in Pediatrics, vol. 7, no. 4, pp. 466–471, 1995. View at Google Scholar · View at Scopus
  34. G. D. Reeves and D. A. Doyle, “Growth hormone treatment and pseudotumor cerebri: coincidence or close relationship?” Journal of Pediatric Endocrinology and Metabolism, vol. 15, supplement 2, pp. 723–730, 2002. View at Google Scholar · View at Scopus
  35. D. J. Friedman, “Medication-induced intracranial hypertension in dermatology,” American Journal of Clinical Dermatology, vol. 6, no. 1, pp. 29–37, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. F. W. Fraunfelder, F. T. Fraunfelder, and J. J. Corbett, “Isotretinoin-associated intracranial hypertension,” Ophthalmology, vol. 111, no. 6, pp. 1248–1250, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. R. H. Spector and J. Carlisle, “Pseudotumor cerebri caused by a synthetic vitamin A preparation,” Neurology, vol. 34, no. 11, pp. 1509–1511, 1984. View at Google Scholar · View at Scopus
  38. T. Schroeter, C. Lanvers, H. Herding, and M. Suttorp, “Pseudotumor cerebri induced by all-trans-retinoic acid in a child treated for acute promyelocytic leukemia,” Medical and Pediatric Oncology, vol. 34, no. 4, pp. 284–286, 2000. View at Google Scholar
  39. Tretinoin, 2011, http://www.factsandcomparisons.com/facts-comparisons-online.aspx.
  40. M. F. Guirgis and G. T. Lueder, “Intracranial hypertension secondary to all-trans retinoic acid treatment for leukemia: diagnosis and management,” Journal of the American Association for Pediatric Ophthalmology and Strabismus, vol. 7, no. 6, pp. 432–434, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Y. Chen, R. K. Tsai, and S. M. Huang, “ATRA-induced pseudotumour cerebri-one case report,” Kaohsiung Journal of Medical Sciences, vol. 14, no. 1, pp. 58–60, 1998. View at Google Scholar · View at Scopus
  42. C. Selleri, F. Pane, R. Notaro et al., “All-trans-retinoic acid (ATRA) responsive skin relapses of acute promyelocytic leukaemia followed by ATRA-induced pseudotumour cerebri,” British Journal of Haematology, vol. 92, no. 4, pp. 937–940, 1996. View at Google Scholar · View at Scopus
  43. S. Naderi, S. Nukala, F. Marruenda, P. Kudarvalli, and P. R. Koduri, “Pseudotumour cerebri in acute promyelocytic leukemia: improvement despite continued ATRA therapy,” Annals of Hematology, vol. 78, no. 7, pp. 333–334, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Tiamkao and C. Sirijirachai, “Pseudotumor cerebri caused by all-trans-retinoic acid: a case report,” Journal of the Medical Association of Thailand, vol. 83, no. 11, pp. 1420–1423, 2000. View at Google Scholar · View at Scopus
  45. S. K. Mishra, S. R. Melinkeri, and S. Dabadghao, “Benign thymic hyperplasia after chemotherapy for acute myeloid leukemia,” European Journal of Haematology, vol. 67, no. 4, pp. 252–254, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. O. Sakamoto, M. Yoshinari, T. Rikiishi et al., “Hypercalcemia due to all-trans retinoic acid therapy for acute promyelocytic leukemia: a case report of effective treatment with bisphosphonate,” Pediatrics International, vol. 43, no. 6, pp. 688–690, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Decaudin, Adams D, P. Naccache, L. Castagna, and J. N. Munck, “Maintained all-trans retinoic acid therapy in a patient with pseudotumour cerebri despite aggravated symptoms,” Leukemia and Lymphoma, vol. 27, no. 3-4, pp. 373–374, 1997. View at Google Scholar · View at Scopus
  48. F. Sano, K. Tsuji, N. Kunika et al., “Pseudotumor cerebri in a patient with acute promyelocytic leukemia during treatment with all-trans retinoic acid,” Internal Medicine, vol. 37, no. 6, pp. 546–549, 1998. View at Google Scholar · View at Scopus
  49. B. Machner, B. Neppert, M. Paulsen, C. Hofmann, T. Sander, and C. Helmchen, “Pseudotumor cerebri as a reversible side effect of all-trans retinoic acid treatment in acute promyelocytic leukaemia,” European Journal of Neurology, vol. 15, no. 7, pp. e68–e69, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. P. Gallipoli, “Pseudotumour cerebri as a manageable side effect of prolonged all-trans retinoic acid therapy in an adult patient with acute promyelocytic leukaemia,” European Journal of Haematology, vol. 82, no. 3, pp. 242–243, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. G. Varadi, A. Lossos, R. Or, J. Kapelushnik, and A. Nagler, “Successful allogeneic bone marrow transplantation in a patient with ATRA-induced pseudotumor cerebri,” American Journal of Hematology, vol. 50, no. 2, pp. 147–148, 1995. View at Google Scholar · View at Scopus
  52. R. Naithani, R. Kumar, and P. Mishra, “Pseudotumor cerebri in a child in early phase of induction therapy for APL with ATRA,” Indian Journal of Pediatrics, vol. 76, no. 4, pp. 439–440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. M. Colucciello, “Pseudotumor cerebri induced by all-trans retinoic acid treatment of acute promyelocytic leukemia,” Archives of Ophthalmology, vol. 121, no. 7, pp. 1064–1065, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Ganguly, “All-trans retinoic acid related headache in patients with acute promyelocytic leukemia: prophylaxis and treatment with acetazolamide,” Leukemia Research, vol. 29, no. 6, p. 721, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. S. De Botton, V. Coiteux, S. Chevret et al., “Outcome of childhood acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy,” Journal of Clinical Oncology, vol. 22, no. 8, pp. 1404–1412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. K. S. Dixon and A. Hassoun, “Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole,” Journal of the American Pharmacists Association, vol. 50, no. 6, pp. 742–744, 2010. View at Google Scholar · View at Scopus
  57. H. H. Mahmoud, C. A. Hurwitz, W. M. Roberts, V. M. Santana, R. C. Ribeiro, and R. A. Krance, “Tretinoin toxicity in children with acute promyelocytic leukaemia,” The Lancet, vol. 342, no. 8884, pp. 1394–1395, 1993. View at Publisher · View at Google Scholar · View at Scopus
  58. M. D. Čolović, G. M. Janković, I. Elezović et al., “Effect of all-trans-retinoic acid alone or in combination with chemotherapy in newly diagnosed acute promyelocytic leukaemia,” Medical Oncology, vol. 14, no. 2, pp. 65–72, 1997. View at Google Scholar · View at Scopus
  59. G. Mann, D. Reinhardt, J. Ritter et al., “Treatment with all-trans retinoic acid in acute promyelocytic leukemia reduces early deaths in children,” Annals of Hematology, vol. 80, no. 7, pp. 417–422, 2001. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Bapna, R. Nair, K. S. Tapan et al., “All-trans-retinoic acid (ATRA): pediatric acute promyelocytic leukemia,” Pediatric Hematology and Oncology, vol. 15, no. 3, pp. 243–248, 1998. View at Google Scholar · View at Scopus
  61. R. P. Warrell Jr., S. R. Frankel, W. H. Miller et al., “Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid),” New England Journal of Medicine, vol. 324, no. 20, pp. 1385–1393, 1991. View at Google Scholar · View at Scopus
  62. M. A. Smith, P. C. Adamson, F. M. Balis et al., “Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer,” Journal of Clinical Oncology, vol. 10, no. 11, pp. 1666–1673, 1992. View at Google Scholar · View at Scopus
  63. “Healthy Weight—it’s not a diet, it’s a lifestyle!,” 2011, http://www.cdc.gov/healthyweight/index.html.