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Case Reports in Oncological Medicine
Volume 2013, Article ID 131695, 3 pages
http://dx.doi.org/10.1155/2013/131695
Case Report

Merkel Cell Carcinoma of the Retroperitoneum with No Identifiable Primary Site

Department of Clinical Oncology A, Sapienza University of Rome, Policlinico Umberto Primo, Viale Regina Elena 324, 00161 Rome, Italy

Received 24 May 2013; Accepted 1 August 2013

Academic Editors: B. I. Razzouk and D. Yin

Copyright © 2013 Daniele Rossini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Merkel cell carcinoma (MCC) is an extremely rare primary neuroendocrine neoplasm of the skin that shows aggressive behavior and a poor prognosis. We report a case of a 67-year-old male with a Merkel cell carcinoma which initially presented itself as a large retroperitoneal mass. Pathological and immunohistochemical analysis revealed tissue consistent with neuroendocrine carcinoma. Despite complete medical workup, no other primary MCC could be detected. While being an atypical presentation, the tumor mass showed an excellent response to the combination of chemotherapy followed by radiotherapy.