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Case Reports in Oncological Medicine
Volume 2013 (2013), Article ID 234391, 4 pages
http://dx.doi.org/10.1155/2013/234391
Case Report

Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation

Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, 09010 Aydın, Turkey

Received 13 July 2013; Accepted 2 September 2013

Academic Editors: L. Beex, J. I. Mayordomo, and O. Ozyilkan

Copyright © 2013 Esin Oktay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine.