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Case Reports in Oncological Medicine
Volume 2013, Article ID 370179, 3 pages
http://dx.doi.org/10.1155/2013/370179
Case Report

Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature

1Egas Moniz, Health Sciences Institute, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
2Serviço de Hematologia, Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Rua Professor Lima Basto, 1099-023 Lisboa, Portugal
3Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Rua Professor Lima Basto, 1099-023 Lisboa, Portugal
4Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, Portugal

Received 30 March 2013; Accepted 20 April 2013

Academic Editors: L. Beex, J. M. Buchanich, D. V. Jones, C. V. Reyes, and K. Tanaka

Copyright © 2013 Carlos Zagalo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Burkitt's lymphoma (BL) is an aggressive B-cell malignancy with very high proliferation rate, more common in males than females. Here, we describe a case of Burkitt's lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. Supportive treatment was administered until early delivery, after which the patient was treated according to protocol LMB96. Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.