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Case Reports in Oncological Medicine
Volume 2013, Article ID 728479, 5 pages
http://dx.doi.org/10.1155/2013/728479
Case Report

Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature

1Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, India
2Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, India

Received 11 December 2012; Accepted 13 January 2013

Academic Editors: S. Aksoy, J. M. Buchanich, J. Itami, Y.-F. Jiao, G. Tallini, and K. Tanaka

Copyright © 2013 Nagesh T. Sirsath et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma. In contrast to the other regions, neuroendocrine tumours of the sinuses have been reported to be recurrent and locally destructive. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. Difficulty in pathologic diagnosis and rarity of this malignancy have hindered the progress in understanding the clinical course and improving outcomes. We herein report a case of poorly differentiated neuroendocrine tumour of ethmoid and sphenoid sinus with invasion of orbit and intracranial extension. The patient had complete response at the end of chemoradiation and he was disease-free for 9 months duration after which he developed bone metastasis without regional recurrence.