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Case Reports in Oncological Medicine
Volume 2014, Article ID 194636, 5 pages
http://dx.doi.org/10.1155/2014/194636
Case Report

Her-2 Positive Gastric Cancer Presented with Thrombocytopenia and Skin Involvement: A Case Report

1Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 0700 Antalya0700 Antalya, Turkey
2Department of Medical Oncology, Faculty of Medicine, Afyon Kocatepe University, Izmir Karayolu 8.km, 03200 Afyon, Turkey

Received 14 February 2014; Accepted 10 June 2014; Published 23 June 2014

Academic Editor: Jose I. Mayordomo

Copyright © 2014 Deniz Arslan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer is the 5th most frequent cancer around the world and the 3rd most frequent reason of deaths due to cancer. Every year, about 1 million new cases are taking place, with varying geographical distribution. Gastric cancer is often metastatic to liver, lungs, and bones in hematogenous way, to peripheral lymph nodes in lymphogenous way, and to peripheral tissues in adjacency way, yet bone marrow (BM) and cutaneous metastasis are quite seldom. Pancytopenia is a more frequent finding identified in BM metastasis of solid organ cancers, and isolated thrombocytopenia is less often. The human epidermal growth factor 2 (HER-2) is positive in gastric cancer at a rate of 7–34%. Here, we have presented our HER-2 positive gastric cancer incident which presented with BM and cutaneous metastasis, and has no 18F-fluoro-2-deoxi-D-glucose (FDG) involvement except bone metastases.