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Case Reports in Oncological Medicine
Volume 2014, Article ID 341980, 5 pages
http://dx.doi.org/10.1155/2014/341980
Case Report

Adult Neuroblastoma Complicated by Increased Intracranial Pressure: A Case Report and Review of the Literature

1Divisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA
2Department of Pathology, Microbiology, and Immunology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA
3Division of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USA

Received 6 June 2014; Revised 30 August 2014; Accepted 3 September 2014; Published 25 September 2014

Academic Editor: Ossama W. Tawfik

Copyright © 2014 Patrick L. Stevens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neuroblastoma is the third most commonly occurring malignancy of the pediatric population, although it is extremely rare in the adult population. In adults, neuroblastoma is often metastatic and portends an extremely poor overall survival. Our case report documents metastatic neuroblastoma occurring in a healthy 29-year-old woman whose course was complicated by an unusual presentation of elevated intracranial pressures. The patient was treated with systemic chemotherapy, I131 metaiodobenzylguanidine (MIBG) radiotherapy, and autologous stem cell transplant (SCT). Unfortunately the patient’s response to therapy was limited and she subsequently died. We aim to review neuroblastoma in the context of increased intracranial pressure and the limited data of neuroblastoma occurring in the adult population, along with proposed treatment options.