Number Age (years) Sex Primary site Systemic metastasis CNS site Size of CNS tumor (cm) Interval between diagnosis of primary and diagnosis of CNS metastasis Treatment for CNS tumor Mutational status Survival prognosis after diagnosis of CNS metastasis References 1 75 M Mesentery Liver Both hemispheres Infiltrative 14 months Imatinib 800 mg/day NA CR (4 months)
Brooks et al. (2002) [12 ] 2 70 M Stomach Lung Left occipital lobe 5.5 10 years Total resection, radiation NA 8 months Inage et al. (2002) [17 ] 3 47 M Jejunum Liver Left parasagittal ND 25 months Total resection, imatinib 800 mg/day KIT (exon 9) 35 months Hughes et al. (2004) [16 ] 4 60 M Small intestine Lumbosacral vertebrae (L5-S1) Left cavernous sinus ND 7 years Radiation (54 Gy) NA 8 months Akiyama et al. (2004) [9 ] 5 76 M Duodenum and jejunum ND Right parietal, right cerebellar hemisphere 2 4 months Imatinib 400 mg/day, radiation (40 Gy) No mutation in KIT (exon 11) 4 months Kajikawa et al. (2005) [19 ] 6 68 F Perisacral ND Right parietal lobe 3 2 years Total resection, imatinib 800 mg/day NA CR Kaku et al. (2006) [20 ] 7 42 M Mesentery ND Right parietal lobe 3.5 Mesentery lesion later discovered Total resection, radiation (60 Gy), imatinib 600 mg/day NA 10 months Puri et al. (2006) [21 ] 8 45 M Small intestine ND Pontomedullary junction, cerebellum, leptomeningeal 2 5 years Imatinib 800 mg/day NA 2 months Gerin et al. (2007) [15 ] 9 49 F Mesentery Liver Left eye, brain 0.24 3 years Imatinib 400 mg/day NA 9 months Gentile et al. (2008) [14 ] 10 54 F Esophagus Liver Left frontal lobe 5 6 years Total resection, imatinib 400 mg/day, SRT KIT (exon 11) CR (6 months) Hamada et al. (2010) [10 ] 11 77 M Jejunum ND Right cerebral peduncle, 2.4 Jejunum lesion Total resection, radiation (39 Gy), imatinib 400 mg/day No mutation in KIT (exons 11, 13, 17, and 19), and PDGFR 4 months Naoe et al. (2011) [11 ] 12 26 M Duodenum Liver Left frontotemporal 6.1 × 4.1 6 years Total resection, radiation NA CR (4 months) Wong and Chu (2011) [22 ] 13 15 M Stomach Liver Right frontoparietal 4.2 × 3.3 12 years Total resection, sorafenib 800 mg/day, sunitinib 37.5 mg/day No mutation in KIT (exons 9, 11, 13, and 17), and PDGFR CR (6 months) Jagannathan et al. (2012) [18 ] 14 74 M Jejunum Liver Right prefrontal gyrus 1.5 × 1.4 6 years Sunitinib 50 mg/day, SRS NA CR (9 months) Takeuchi et al. (2013) [8 ] 15 57 M Stomach ND Left cerebellar, Left frontal 3 13 months Total resection, SRS (18 Gy) NA CR (15 months) Drazin et al. (2013) [13 ] 16 80 M Small intestine Cardiac apex, subclavial Cerebellar vermis, Right frontal 4 Small intestine lesion later discovered Total resection, RT (22 Gy) NA 4 months present case
