Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients

Figure 2

Gadolinium-enhanced T1-weighted MRI images obtained (a) 2 months after initiation of corticosteroids and (b) after surgical resections. Histopathological examination indicating (c) tissue necrosis and fibrinoid necrosis of small blood vessels (Hematoxylin and Eosine (H&E) staining, ×200); (d) H&E staining (×400); (e) radionecrosis surrounding gliosis and inflammatory cell reaction (H&E staining, ×200); and (f) focal infiltration of inflammatory cells and subpial gliosis (H&E, staining ×400).

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