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Case Reports in Oncological Medicine
Volume 2014, Article ID 731581, 4 pages
http://dx.doi.org/10.1155/2014/731581
Case Report

Importance of HER2 Work-Up and Treatment Even in Patients with Poor Performance Status: A Case Report

1Department of Medical Oncology, School of Medicine, Gaziantep University, Kilis Yolu Uzeri, 27310 Gaziantep, Turkey
2Depatment of Internal Medicine, Harran University School of Medicine, Sanliurfa, Turkey

Received 21 February 2014; Accepted 31 March 2014; Published 13 April 2014

Academic Editor: Sercan Aksoy

Copyright © 2014 Ali Suner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer is one of most common types of cancers. Metastatic gastric cancer has a poor prognosis and is accepted as incurable at this stage. Treatment of metastatic gastric cancer did not progress substantially until new targeted agents have come out. Recently published ToGA trial showed promising results in HER2 overexpressing metastatic gastric cancer. In this case we present a case with an excellent complete response with anti-HER2 treatment. Most importantly, we wanted to emphasize (1) the importance of early determination of HER2 overexpression, and (2) to draw attention of anti-HER2 agents in the first line treatment even in patients with a poor performance status.