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Case Reports in Oncological Medicine
Volume 2014, Article ID 790192, 4 pages
http://dx.doi.org/10.1155/2014/790192
Case Report

Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases

Tufts University School of Medicine, 800 Washington Street, Suite 7S-7099, Boston, MA 02111, USA

Received 12 December 2013; Accepted 10 February 2014; Published 12 March 2014

Academic Editors: C. Gennatas and K. Tanaka

Copyright © 2014 Muhammad Wasif Saif. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Liver metastases are commonly encountered in patients presenting with metastatic colorectal cancer (mCRC); resection is the treatment of choice. A number of systemic treatment options are currently available for such patients, including the use of 5-fluorouracil-based chemotherapies and oxaliplatin (e.g., FOLFOX) in combination with biologic agents that target angiogenesis (e.g., bevacizumab). For patients with progression following first-line treatment, current second-line options include a change in chemotherapy with bevacizumab (for patients who did or did not receive prior bevacizumab) or FOLFIRI in combination with aflibercept, a more recently approved antiangiogenesis therapy. Neurotoxicity is a well-established adverse event of oxaliplatin-based therapy. The current case details an mCRC patient with liver metastases who was treated with a capecitabine and oxaliplatin regimen (XELOX), and experienced two episodes of transient cortical blindness possibly related to oxaliplatin. After disease progression, the patient was switched to a regimen of FOLFIRI and aflibercept and did well on this second-line regimen.