Axillary Metaplastic Breast Carcinoma with Ipsilateral Pectoral Invasive Ductal Carcinoma: An Unusual Presentation

Figure 1

Invasive ductal carcinoma in the left breast before (a) and after (b) neoadjuvant therapy and axillary metaplastic breast carcinoma (c). (a) Cellular tumor clusters with poor tubular formation (×20), moderate pleomorphism and occasional mitosis (×100 inset). (b) Tumor islets separated by fibrosis (×20), composed of cells with cytoplasmic empty vacuoles and occasional pyknosis consistent with therapy effect (×100 inset). (c1) Intertwining spindle cells, adenocarcinoma, and squamous cell carcinoma (×40). (c2) Vascular invasion (×20). (c3–c5) Spindle and poorly differentiated squamous components with different stains. (c3) HE (×40); (c4) AE1/AE3 (×40); (c5) smooth muscle myosin heavy chain (×40).