Case Reports in Oncological Medicine / 2015 / Article / Tab 1 / Case Report
Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature Table 1 Reported cases of pulmonary toxicity related to oxaliplatin
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References number Patient age/gender Aim of treatment Cumulative dose of oxaliplatin (mg/m2 ) Number of cycles Regimen Previous lung disease Outcome [4 ] 60/M Metastatic disease 910 7 FOLFOX None Resolved [5 ] 60/F Metastatic disease NA NA FOLFOX None Resolved [6 ] 68/F Adjuvant 510 6 FOLFOX/single agent oxaliplatin None Death
[7 ] 64/M Metastatic disease (gastric ca) 200 2 FOLFOX None Resolved 75/M Metastatic disease (gastric ca) 100 1 FOLFOX None Resolved [8 ] 74/M Adjuvant 510 6 FOLFOX None Death [9 ] 67/M Metastatic disease (HCC) 1100 11 FOLFOX Pulmonary artery stenosis, lung metastases Resolved
[10 ] 62/M Adjuvant 595 7 FOLFOX None Death 77/M Metastatic disease 595 7 FOLFOX None Resolved [11 ] 30/F Adjuvant 510 6 FOLFOX None Resolved [12 ] 66/M Metastatic disease 1020 12 FOLFOX None Death
[13 ] 73/F Metastatic disease 340 4 FOLFOX Lung metastases Death 71/M Adjuvant 340 4 FOLFOX Wegener’s granulomatosis, mild COPD Death [14 ] 82/M Metastatic disease 850 10 FOLFOX None Resolved
[15 ] 71/M Adjuvant 510 6 FOLFOX Mild interstitial lung disease Death 77/F Adjuvant 1020 12 FOLFOX Asymptomatic ground glass opacities at right lung base Resolved 69/M Adjuvant NA 6 FOLFOX Asymptomatic subpleural infiltrate Resolved partially [16 ] 76/M Metastatic disease 260 2 XELOX None Death [17 ] 47/M Metastatic disease NA NA XELOX + bevacizumab Lung metastases Resolved
[18 ] 55/M Metastatic disease 1105 13 FOLFOX None Death 73/M Adjuvant 765 9 FOLFOX Emphysematous lungs Death [19 ] 69/F Metastatic disease 595 7 FOLFOX + cetuximab Malignant pleural effusion Death
[20 ] 73/F Metastatic disease 1785 11 FOLFOX + bevacizumab Smoking, suspected lung metastases Death 75/M Metastatic disease (gastric ca) 765 9 FOLFOX Lung metastases Death 64/M Adjuvant 1020 12 FOLFOX Smoking Death [21 ] 57/M Metastatic disease 765 9 NA None Resolved
Current paper 65/F Metastatic disease 1020 12 FOLFOX + bevacizumab None Death 80/M Advanced locoregional disease 1445 17 FOLFOX + bevacizumab None Death
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