Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver

Figure 4

(a) A nodular proliferating mass (blue star) under the skeletal muscle (thick arrow) and fascia (arrow head) (H&E, ×10). (b) The tumor reveals trabecular or acinar arrangement surrounded by sinusoidal vessels (H&E, ×200). The individual tumor cells are hepatoid (thick eosinophilic and granular cytoplasm, round central nuclei, prominent nucleoli). (c) Some tumor cells are pleomorphic with frequent multinucleation (Edmondson-Steiner Nuclear grade 4/4) (H&E, ×400).