PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV

Figure 1

Changes in tumor size and correlation with laboratory results in patient 1. After 3 cycles, index right breast lesion (A-B, lower panel) increased in size while index right pulmonary lesion decreased in size consistent with immune-related response pattern (A-B, upper panel). After 6 cycles, both lesions had decreased in size significantly (C, upper and lower panels). Although pembrolizumab treatment was associated with grade 1 leucopenia and grade 1 ALT/AST elevations initially, total white count and ALT/AST levels subsequently stabilized (graph). HCV viral load fluctuated between 3.36 IU/mL (6.53 log IU/mL) and 5.17 IU/mL (6.71 log IU/mL) before initiation of ledipasvir and sofosbuvir in April 2015. After 12-week course, HCV viral load became undetectable and remains so. To date, she has completed 15 cycles to date with ongoing excellent partial response.