Case Report

Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma

Table 2

Tumor markers comparison between third and fourth surgeries.

Ki-67 (%)p53ACTH (IHQ)

2009 (after 3rd surgery)<5%No evidence>50%
2012 (after 4th surgery)10–15%25%>50%

Considerations: The Ki-67 and p53 immunohistochemical exams were made with primary monoclonal antibody performed with 1 : 50 dilution, according to the manufacturer’s protocol.