Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature

Figure 3

Pathology of the fragmented CPA tumor mass demonstrated poorly differentiated neuroendocrine carcinoma (small cell). (a) The tumor was highly cellular with tumor cells demonstrating a high nuclear to cytoplasmic ratio and molded nuclei (64x). (b) Higher magnification revealed characteristic finely granular, “salt and pepper” chromatin and frequent mitoses (254x). Both photomicrographs are of an H&E stained section. A Ki-67 proliferation index was high, and neoplastic cells were positive for cytokeratin, synaptophysin, and CD56 (not shown).

(a)

(b)