Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature

Table 1

Authors	Patient sex	Age	Presenting symptoms	Primary site	Imaging identification of metastasis	Metastasis site	Treatment	Outcome
Tewari et al. [19]	Female	47	Rising serum chromogranin A on follow-up	Gallbladder	18-FDG PET/CT	Left parietooccipital	RT	Survived
Freedy and Miller [16]	Male	63	Generalized weakness, inappropriate language, jerking movements RUE and RLE	Prostate	Contrast-enhanced CT	Left hemisphere, periventricular	Chemotherapy, palliative measures	Died, 7 days later
Zachariah et al. [20]	Male	72	Confusion, unsteady gait, progressive difficulty talking	Prostate	Contrast-enhanced CT and MRI	Multiple cystic lesions, single right cerebellar hemisphere lesion	WBRT: 30 Gy in 10 treatments	Died, 6 weeks later
Isaka et al. [17]	Male	67	Increasing severity headache	Bladder	CT, T1 and T2, MRI	Cystic lesion left frontal lobe	STR, WBRT: 40 Gy in 20 fractions	Died, 4 months later
Erasmus et al. [15]	Male	70	Left homonymous hemianopsia	Prostate	CT and MRI	Right optic radiation	20 Gy in 5 fractions, booster dose of 15 Gy in 5 doses	Died, 4 months later
Madroszyk et al. [18]	Male	69	General fatigue, 5 kg weight loss	Esophagus	CT	Multiple metastasis	Not discussed	Died, 22 months later
	Male	48	Confusion	Esophagus	CT	Multiple metastasis	RT and corticotherapy	Died, 10 months later
Hussein et al. [21]	Female	50	Vertigo, ataxia, nausea, vomiting	Rectum	CT	Right cerebellar mass	SR, RT (3000 rads)	Survived
	Male	43	Bifrontal headaches, stuporous, right hemiplegia	Colon	CT	Right frontal lobe, left basal ganglion, left subcortical frontal region	SR, RT (3000 rads)	Survived
Mallory et al. [22]	10 M; 5 F	58 (average)	Sensorimotor (6) headache (4), seizures, hydrocephalus, carcinoid syndrome (3)	Lung (7), stomach (4), pancreas (1), large intestine (2), thymus (1), kidney (2), unknown (1)	N/A	Brain	SR (12), GKS (2), WBRT (1)	2 alive at last follow-up, median overall survival 19 months

[15–22].
RUE: right upper extremity, RLE: right lower extremity, RT: radiation therapy, SR: surgical resection, STR: subtotal resection, WBRT: whole brain radiation therapy, and GKS: Gamma Knife surgery.