A Case of Primary Breast Diffuse Large B-Cell Lymphoma Treated with Chemotherapy Followed by Elective Field Radiation Therapy: A Brief Treatment Pattern Review from a Radiation Oncologist’s Point of View

Table 1

Brief review of treatment modalities and results in PBL patients with DLBCL.

Author [Ref]		Age (median)	Treatment modality						Results
			Surgery (%)	CTx		RT (%)			CR (%)	CNS relapse (%)	Survival (%)
				CHOP (%)	Rituximab (%)	(%)	Field	RT dose; (Gy/Fx)			5 Y-OS	PFS
Avilés et al. [17]	96	58	0	66 (69)	0	64 (67)	IFRT	45/20	69 (72)	11 (11.5)	76 (10 Y)	83 (10 Y)
Yoshida et al. [19]	15	68	11 (73)	12 (80)	0	NA	NA-	NA	NA	0	NA	NA
Avilés et al. [15]	32	46	NA	32 (100)	32 (100)	32 (100)	IFRT	45/20	28 (87)	0	63 (3 Y)	75 (3 Y)
Salzberg et al. [20]	75	62	NA	68 (91)	52 (69)	51 (68)	NA	NA	NA	10 (13.3)	75	65
Mouna et al. [21]	7	50	4 (57)	6 (86)	2 (29)	2 (29)	EFRT	36–50	7 (71.4)	0	NA	NA
Seker et al. [22]	9	49	0	8 (89)	7 (78)	5 (56)	IFRT, EFRT	NA	7 (77.7)	0	76.2	NA
Yhim et al. [5]	68	48	23 (34)	66 (97)	42 (62)	21 (31)	NA	NA	54 (83.1)	0	60.7	50.3
Niitsu et al. [23]	30	57	NA	30 (100)	11 (37)	18 (60)	IFRT	NA	29 (96.7)	2 (6.7)	87	77
Zhao et al. [24]	1	39	1 (100)	1 (100)	1 (100)	1 (100)	IFRT	40/NA	100	0	NA	NA
Validire et al. [25]	38	62	NA	36 (95)	4 (10)	27 (71)	IFRT, CNS PRT	40/20; 18/10	34 (89)	3 (6.7)	61	54
Present study	1	44	no	1 (100)	1 (100)	1 (100)	EFRT	50.4/28	100	0	NA	NA

Ref: references; : total number of patients; NA: not applicable; Gy: Gray; Fx: fractionation; CTx: chemotherapy; RT: radiation therapy; 5 Y-OS: 5-year overall survival; PFS: progression-free survival; CR: complete response; IFRT: involved field radiation therapy; EFRT: elective field radiation therapy; CNS PRT: central nervous system prophylactic radiation therapy.