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Case Reports in Oncological Medicine
Volume 2015 (2015), Article ID 953857, 9 pages
http://dx.doi.org/10.1155/2015/953857
Case Report

Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report

1Department of Radiation Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
2Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
3Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

Received 5 December 2014; Accepted 30 January 2015

Academic Editor: Nurdan Tacyildiz

Copyright © 2015 Chase C. Hansen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An inflammatory myofibroblastic tumor (IMT) is an immunohistochemically diverse entity demonstrating neoplastic and nonneoplastic qualities. Although IMTs can arise in any area of the body, lesions arising in certain sites, namely, the nasal cavity, paranasal sinuses, and pterygopalatine fossa, demonstrate a heightened neoplastic and invasive potential. Despite case specific complete tumor regression and disease remission in response to pharmacotherapeutics, a subset of IMTs remain resistant to all forms of therapy. We present such a case, a 34-year-old female patient, with a highly resistant, maxillary sinus IMT. Her refractory, ALK-1 negative IMT has not responded well to novel therapies reported in current literature. This case suggests the role of zonal expressivity within a single lesion as a probable mechanism for its highly resistant nature and should promote determination of each IMT’s cytogenetic profile to provide more effective targeted therapy. Paper includes a literature review of all maxillary sinus IMTs from 1985 to 2014 along with their immunohistochemical staining, treatments, and outcomes.