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Case Reports in Oncological Medicine
Volume 2015, Article ID 964687, 4 pages
http://dx.doi.org/10.1155/2015/964687
Case Report

Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid

1Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway
2Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9038 Tromsø, Norway
3Department of Pathology, Nordland Hospital, 8092 Bodø, Norway
4Department of Pulmonology, Nordland Hospital, 8092 Bodø, Norway

Received 15 June 2015; Accepted 27 July 2015

Academic Editor: Jose I. Mayordomo

Copyright © 2015 Carsten Nieder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer. Case Report. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastases. He also developed a series of infections during and after irradiation, and we hypothesize that the immunological events during this phase might have influenced the size of the nonirradiated metastases. Conclusion. Ionizing radiation generates inflammatory signals and, in principle, could provide both tumor-specific antigens from dying cells and maturation stimuli that are necessary for dendritic cells’ activation of tumor-specific T cells. Even if the detailed mechanisms causing nontargeted immune modulatory effects in individual patients are poorly understood, clinical development of radioimmunotherapy is underway.