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Case Reports in Oncological Medicine
Volume 2015, Article ID 968567, 4 pages
Case Report

Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma

1Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA
2Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA
3Department of Hematology/Oncology, Children’s Mercy Hospital, Kansas City, MO 64108, USA
4School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA

Received 9 November 2015; Accepted 13 December 2015

Academic Editor: Nurdan Tacyildiz

Copyright © 2015 Katherine Moore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients with hereditary retinoblastoma have a heightened risk of developing subsequent bone and soft tissue sarcomas, exacerbated by radiation and alkylating chemotherapy. Secondary leiomyosarcomas are rare. A 29-year-old patient with bilateral retinoblastoma history presented with concurrent, independent malignancies found to be Rb-suppressed uterine and Rb-positive bladder leiomyosarcomas. She had undergone both ifosfamide chemotherapy and radiation therapy but demonstrated rare simultaneous primary leiomyosarcomas not previously described in association with ifosfamide. This rare case underlines the protean genetic predisposition to malignancy in this patient population, heightening awareness of lifelong malignancy potential, and the necessity for continuous periodic screening.