Novel Brentuximab Vedotin Combination Therapies Show Promising Activity in Highly Refractory CD30+ Non-Hodgkin Lymphoma: A Case Series and Review of the Literature

Figure 1

(a) Sagittal view of the sinus on computerized tomography (CT) showing the complete opacification of the right sphenoid sinus which was proven to be ALCL involvement by biopsy. (b) Axial view of CT C/A/P obtained at the time of diagnosis showing the diffuse osseous metastatic spread of disease involving vertebral bodies, pelvis, and humerus. (c) Representative lung field section of the CT C/A/P in (b) showing the numerous subcentimeter nodular densities within the lung parenchyma and along the margins of the fissures and pleural margins. Patient did not have significant lymphadenopathy (not shown). (d) Representative CT lung field performed after the first dose of hyperCVAD without BV showing interval progression of lung disease as well as development of new right hilar adenopathy (not shown). (e) Representative lung field of PET-CT (level approximates that of image (d)) showing resolution on the reticulonodular opacities and decrease in size of the largest subpleural nodule in the L lung. No PET avidity noted. Not shown are persistent diffuse lytic lesions that are not PET avid.

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