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Case Reports in Oncological Medicine
Volume 2016, Article ID 6980198, 4 pages
Case Report

A Novel Case of Penile Gangrene in a Patient Treated with Ibrutinib for Chronic Lymphocytic Leukemia

1Department of Internal Medicine, University of Florida, Gainesville, FL, USA
2Department of Internal Medicine, University of Central Florida, Orlando, FL, USA
3Cancer Specialists of North Florida, Saint Augustine, FL, USA
4Division of Hematology and Oncology, Department of Internal Medicine, University of Florida, Gainesville, FL, USA

Received 24 July 2016; Accepted 6 November 2016

Academic Editor: Raffaele Palmirotta

Copyright © 2016 William Paul Skelton IV et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene was self-limited upon discontinuing ibrutinib. Conclusion. Our finding describes a very rare yet important adverse event associated with ibrutinib use.