Testicular Signet-Ring Cell Metastasis from a Carcinoma of Unknown Primary Site: A Case Report and Literature Review

Table 1

Reported cases of CUP with testicular metastases.

Author	Patient	Presenting symptom	Disease extent	Histological findings
Salesi et al. 2004 [9]	62-year-old male	Dyspnea and left testicular mass	Multiple lung metastases, pleural effusion, mediastinal node involvement, brain metastasis, and testicular metastasis	Metastatic adenocarcinoma (testicular biopsy and VATS)
Chimakurthi  and Lalit 2008 [10]	37-year-old male	Ascites and right scrotal swelling	Diffuse carcinomatosis involving most of the abdominal organs, bowel obstruction, and frozen retroperitoneum	Metastatic adenocarcinoma with signet ring cells; (testicular biopsy and omental biopsy)
Saredi et al. 2011 [11]	77-year-old male	Right testicular swelling	Pulmonary metastases and peritoneal carcinomatosis	Signet ring adenocarcinoma (testicular biopsy); Acinar prostatic adenocarcinoma (prostatic biopsy)
Kollas et al. 2006 (present case)	56-year-old male	Ascites and right testicular swelling	Peritoneal, testicular, and pleural metastases	Poorly differentiated carcinoma composed of signet ring cells