Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2016, Article ID 8190950, 5 pages
http://dx.doi.org/10.1155/2016/8190950
Case Report

Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature

1Department of Radiation Biology, The Finsen Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
2Department of Neurosurgery, The Neurocenter, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
3Department of Clinical Physiology, Nuclear Medicine and PET, Center of Diagnostic Investigation, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
4Department of Pathology, Center of Diagnostic Investigation, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
5Department of Oncology, The Finsen Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

Received 17 February 2016; Revised 12 April 2016; Accepted 18 April 2016

Academic Editor: Didier Frappaz

Copyright © 2016 Maria Dinche Johansen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Extracranial metastases from glioblastoma are rare. We report two patients with extracranial metastases from glioblastoma. Case 1 concerns a 59-year-old woman with multiple metastases that spread early in the course of disease. What makes this case unusual is that the tumor had grown into the falx close to the straight sinus and this might be an explanation to the early and extensive metastases. Case 2 presents a 60-year-old man with liver metastasis found at autopsy, and, in this case, it is more difficult to find an explanation. This patient had two spontaneous intracerebral bleeding incidents and extensive bleeding during acute surgery with tumor removal, which might have induced extracranial seeding. The cases presented might have hematogenous spreading in common as an explanation to extracranial metastases from GBM.