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Case Reports in Oncological Medicine
Volume 2016, Article ID 8353745, 4 pages
Case Report

Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases

1Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
2Department of Histology and Embryology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
3Department of Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
4Department of Urology, General Hospital of Florina, Florina, Greece

Received 20 July 2016; Accepted 25 September 2016

Academic Editor: Jose I. Mayordomo

Copyright © 2016 Aristeidis Hristos Zibis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a case of scrotal apocrine adenocarcinoma in a 72-year-old Caucasian male which was initially presented as a reddish superficial lesion which in time became an ulcerated nodule. The initial pathological examination showed an apocrine adenocarcinoma with pagetoid phenomenon. The tumor recurred after four months and then excision biopsy showed tumor with pagetoid phenomenon which reached all the surgical margins. Three months later an ulcerated nodule in the scrotum and greatly enlarged ipsilateral inguinal lymph nodes were noticed. The final pathological examination showed multiple separated malignant foci, some with overlying pagetoid phenomenon and inguinal lymph node metastases. Immunohistochemistry showed positivity for Gross Cystic Disease Fluid Protein-15 (GCDFP-15), androgen receptors, and score 3+ for the Human Epidermal growth factor Receptor-2 (HER2). The aggressive behavior of the present tumor goes along with previous reports showing that HER2 high score cases exhibit a worse prognosis.