Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2016, Article ID 8961486, 4 pages
Case Report

A Rare Case of Primary Anterior Mediastinal Yolk Sac Tumor in an Elderly Adult Male

1Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
2Department of Hematology/Oncology, University of Arizona Cancer Center, Tucson, AZ 85724, USA

Received 19 February 2016; Accepted 22 March 2016

Academic Editor: Didier Frappaz

Copyright © 2016 Sammy G. Nakhla and Srinath Sundararajan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mediastinal germ cell tumors are extragonadal germ cell tumors (EGGCTs) commonly seen in children and young adults. They are more common in men. Clinically they are classified as teratomas, seminomas, and nonseminomatous germ cell tumors. Primary mediastinal yolk sac neoplasm is an extremely rare tumor. We present here a very rare case of primary yolk sac tumor of the anterior mediastinum in a 73-year-old male. Mediastinal germ cell tumors have a worse prognosis than gonadal germ cell tumors. Chemotherapy followed by adjuvant surgery improves overall response in EGGCTs. However, comorbidities can render treatment with chemotherapy and surgery challenging in elderly patients.