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Case Reports in Oncological Medicine
Volume 2016, Article ID 9751736, 4 pages
Case Report

Plasmablastic Lymphoma Mimicking Acute Pancreatitis

1Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065, USA
2Department of Medicine, Mount Sinai St. Luke’s and Mount Sinai Roosevelt Hospitals, Icahn School of Medicine, New York, NY 10019, USA
3Department of Hematology/Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA

Received 8 November 2015; Accepted 22 December 2015

Academic Editor: Josep M. Ribera

Copyright © 2016 Faisal Inayat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm. It predominantly occurs in the oral cavity of human immunodeficiency virus (HIV)-positive patients and exhibits a highly aggressive clinical behavior. Case Presentation. We describe an unusual case of a 37-year-old HIV-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts. The neoplastic cells were positive for BOB1 and MUM1, partially positive for CD79a, and negative for CD20, CD56, CD138, CD3, CD5, AE1/AE3, and HHV8. Epstein-Barr virus-encoded RNA in situ hybridization was positive. These features were consistent with PBL. The patient was initiated on cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy, demonstrating a striking response. Conclusion. To our research, this is the first report of PBL with the initial presentation of acute pancreatitis. The findings in this case suggest that PBL should be included in the differential diagnosis of pancreatic and peripancreatic tumors.