External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder?

<div>Histopathology of the resected bladder lesion. (a) Low-power field H&amp;E stain reveals invasive poorly differentiated carcinoma infiltrates lamina propria and muscularis propria. (b) High-power field H&amp;E stain reveals large polygonal-shape cells with low nuclear to cytoplasmic ratio, coarse chromatin structure, multiple nucleoli, and high rate of mitosis. (c) Immunohistochemical stain positive for chromogranin and (d) negative for PSA.</div>

Case Reports in Oncological Medicine

fig2

Figure 2

Figure 2: External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? 

Figure 2 | External Beam Radiation and Brachytherapy for Prostate Cancer: Is It a Possible Trigger of Large Cell Neuroendocrine Carcinoma of the Urinary Bladder? 