Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

Table 1

Cases of signet-ring cell carcinoma (SRCC) of the colon reported in the literature.

Age, years/sex	History of inflammatory bowel disease	Initial diagnostic test	Polyps identified	Positive markers	Location in colon	Stage at diagnosis	Metastasis	Chemotherapy	Survival	Citation
9/M	No	CT abdomen/pelvis	Unspecified	Unspecified	Transverse colon, proximal to splenic flexure	Unspecified	Initially not identified, identified after 7 cycles of chemotherapy	Unspecified	One year + 2 weeks	Yang et al. [9]
36/F	No	Unspecified	No	MLH1, PMS2, MSH2, MSH6; microsatellite stability according to PCR	Cecum	IIA (T3 N0 M0)	No	Adjuvant 5-fluorouracil-based therapy with oral capecitabine	N/A	Park et al. [10]
73/M	No	Screening colonoscopy	No	MUC2, MUC5AC positive; MUC6 focally positive; MUC1 negative	Cecum	Unspecified	No	Unspecified	At 26-month postoperative follow-up, patient is in good health	Ohnita et al. [11]
67/M	No	Surveillance colonoscopy for previously resected non-SRCC gastric cancer	Focal cancer in an adenoma, completely resected one year before	Tumor positive for MSH, negative for MLH1	Transverse colon near splenic flexure	Unspecified	No	Unspecified	Alive at 5-year postoperative follow-up	Fu et al. [12]
19/M	Suspected because of inflammation and edema around the ileal wall	Colonoscopy/gastroscopy because of suspected bowel/peritoneal disease observed on computed tomography scan	No	Unspecified	Sigmoid colon	Unspecified	SRCC cells seen in abdominal fluid	FOLFOX-6 with bevacizumab	Still under treatment	Pamukçu et al. [13]
31/M					Rectosigmoid			Unspecified	Unspecified	Tung et al. [14]
17/M	No	Ultrasound showing aperistalsis of a segment of the bowel wall, followed by computed tomography	No	Unspecified	Ascending colon	T4 N2 M1	Unspecified	FOLFOX-6	Alive at 1-year postoperative follow-up	Marone et al. [15]
13/M	No	Lower gastrointestinal barium study and colonofibroscopy	No	Unspecified	Ascending colon	Unspecified	Unspecified	5-fluorouracil, mitomycin, levamisole	Alive at 1-year postoperative follow-up	Ko et al. [16]
25/M	No	Workup for bladder complaints	No	Unspecified	“Rectal diverticulum” (pulled through sigmoid colon), 2 cm above the anus	Unspecified	Infiltrating the bladder and abdominal wall	Unspecified	Alive at 7-month postoperative follow-up	Posey et al. [17]
6/M	No		Yes	Unspecified	Polyp in descending colon	Unspecified	Unspecified	Unspecified	Unspecified	Hamazaki et al. [18]
22/F	No	Double-contrast barium radiography	No	Unspecified	Descending colon	Dukes B carcinoma	No	Unspecified	Followed up for 3 years without recurrence	Nakata et al. [19]

N/A: not applicable.