Small Split Doses of CD34⁺ Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy

Table 1

PBSC support and hematopoietic recovery after postinduction cycles of ICE; comparison of induction and postinduction cycles.

Pts. no.	Cycle no.	Chemotherapy	Number of CD34^+ cells × 10^6/kg	Days to ANC > 1000/mm^3	Days to Plt > 50 × 10^9/L	Fever
1	3	ICE + GM-CSF	0.35	18	20	ND
	4	ICE + GM-CSF	0.35	23	34	Yes
2	3	ICE	0.3	17	21	No
3	3	ICE + G-CSF	0.8	16	22	No
	4	ICE + G-CSF	0.8	16	22	No
	5	ICE + G-CSF	0.8	16	25	No
	6	ICE + G-CSF	0.8	16	25	Yes
4	3	ICE + GM-CSF	1.8	15	22	ND
5	5	ICE + G-CSF	0.82	17	26	No
	6	ICE + G-CSF	0.82	17	26	Yes
Mean	—	—	0.76	17.1	24.3	—
Hematopoietic toxicity		ICE cycles 1 and 2 (n = 10)	ICE cycle 3 and subsequent cycles with PBSC support (n = 10)
Mean days to ANC > 1000/mm^3		17.6	17.1		0.28
Mean days to Plt > 50 × 10^9/L		21.8	24.3		0.053

ND, no data available.